Readdressing Chloramphenicol: Data From a Pediatric Tertiary Care Center

Abstract

The use of chloramphenicol in developing countries is widely supported by the World Health Organization to treat bacterial infections, especially those caused by gram-negative bacteria. Wealthier regions favour other antibiotics, since there are concerns regarding chloramphenicol’s adverse effects, such as aplastic anaemia. Nevertheless, the rise of multidrug resistant-bacteria has brought a growing interest on chloramphenicol as a new strategy to fight antimicrobial resistance, since current reports of its toxicity are very uncommon. This retrospective study intends to characterize the use of chloramphenicol in a tertiary care hospital in Brazil and report adverse reactions.