Thank you for choosing to submit your article to our journal. These instructions will ensure that you have all the information you need so that your paper can go through peer review, production, and publication without any problems. Please take the time to read them to ensure that your article meets the journal's requirements.

Language

The title, abstract and keywords should be presented in English and Portuguese
Manuscripts submitted to Lusíadas Scientific Journal should preferably be written in English of reasonable level. Exceptionally, scientific articles written in Portuguese of Portugal will also be accepted.

Ethical Conduct and Human and Animal Rights

Authors should ensure that the study they submit for publication complies with ethical and legal principles, both during the research and at publication, in particular with the recommendations of the Helsinki Declaration revised in 2013 by the World Medical Association (http:// www.wma.net/en/20activities/10ethics/10helsinki), the ICMJE (www.icmje.org), and the Committee on Publication Ethics (COPE) (http://publicationethics.org/resources/guidelines).

In appropriate cases, authors should demonstrate that the research has been approved by the ethics committee of the institutions involved and that the recommendations have been followed. This information should be included in the content of the article. Any suspected misconduct will be investigated and reported. Images, names, numbers of clinical processes, or other elements that could enable the identification of the participants of the study should not be presented. Studies involving animal experiments should be conducted according to the guidelines set forth in the "Guide for the care and use of laboratory animals" of the National Institutes of Health. All animal studies should also comply with the ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments).
Authors should also consult the current national legislation that regulates this type of studies (Decree-Law nº 113/2013 of August 7, 2013, and any subsequent updates).
It should be clearly stated in the manuscript that the above rules were followed.

Privacy and Informed Consent

Studies on patients or volunteers require ethics committee approval and written informed consent, which should be documented in the article. Authors are responsible for obtaining informed consent (or, when applicable, from the guardian or legally defined representative) for each individual present in photographs, videos, detailed descriptions, even after attempting to conceal their identity. Names, initials, or other forms of identification should be removed from photographs or other images.
Personal data, such as profession or residence, should be omitted, except when scientifically relevant to the work.
Authors should ensure that they do not present data that would allow the patient to be unambiguously identified.

Permissions

All previously published and protected by copyright material, including illustrations, figures and tables should be accompanied by written permission for reproduction from the copyright holders.

Conflict of Interest and Financial Support

There is a conflict of interest when professional judgment about a primary interest (such as patient well-being or research validity) may be influenced by a secondary interest (such as financial gain). Conflicts of interest can be of non-financial nature, such as personal relationships or rivalries, academic competition, or intellectual beliefs. The existence of a conflict of interest can damage the credibility of the journal, the authors, and science itself. All participants in the peer review and publication process (not only authors, but also reviewers, editors and editorial board members of Lusíadas Scientific Journal) should consider their conflicts of interest when fulfilling their roles in the review and publication process of the article and have the obligation to disclose all relationships that may be perceived as potential conflicts of interest. Authors should mention all sources of funding to the study described and their influence on the design of the manuscript or on the decision to submit for publication. The rigor and accuracy of the contents as well as the opinions expressed are the sole responsibility of the authors. Authors are required to disclose all financial and personal relationships that could bias the work.

To prevent ambiguity, authors should explicitly mention whether there are conflicts of interest. All authors should complete and submit the Conflict of Interest Declaration Form (ICMJE Form for Disclosure of Potential Conflicts of Interest ), available at http://www.icmje.org/conflicts-of-interest/. This information will be kept confidential during the review of the manuscript by the reviewers and will not influence the editorial decision but will be published if the article is accepted. If there are no conflicts, authors should mention this fact. 

Clinical Trials

Lusíadas Scientific Journal supports initiatives that contribute to better dissemination of clinical trials. These include prospective registration of clinical trials in appropriate public databases. According to the ICMJE recommendations, Lusíadas Scientific Journal requires the registration of all clinical trials which data are included in papers submitted for publication in this journal
The ICMJE adopts the World Health Organization definition of a clinical trial, which is "any research study that prospectively assigns to human participants, individually or in groups, one or more health-related interventions with the goal of evaluating their health-related outcomes”.
This definition includes phase I through IV trials. The ICMJE defines health-related interventions as "any intervention used to modify a biomedical or health-related outcome" and health-related outcomes as "any biomedical or health-related measure obtained from patients or participants."

Clinical Trial Registration

Registration in a public database of clinical trials is a requirement for publication of clinical trial data in Lusíadas Scientific Journal, in accordance with the recommendations of the International Committee of Medical Journal Editors (ICMJE, http://www.icmje.org). Trials should be registered prior to or at the beginning of the patient recruitment period. The clinical trial registration number (TRN) as well as the date of that registration should be listed at the end of the abstract of the article.

Data Availability

Lusíadas Scientific Journal suggests that all data on which the conclusions of an original research article are based on be made available to readers. It is therefore suggested that authors ensure that their data are available in public repositories (whenever these are available and appropriate), that they be presented in the main manuscript or in additional files, when possible, in a treatable format (e.g., in spreadsheet, and not in pdf). Lusíadas Scientific Journal requires a data availability statement at the end of each manuscript. For drug or medical devices trials, the statement should at least indicate that relevant patient data, properly anonymized, are available upon a justified request to the authors. Clinical trials that began recruiting participants on or after January 1, 2019 should include a data sharing plan in the trial record.
It is suggested that the statement follows one of the following wordings: 

1. If data are made available
   "Data availability: individual patient data [and/or] the complete data set [and/or] the technical appendix [and/or] the specifications of the statistical analysis, are available on [/doi] [with free access/with the restrictions] [from the corresponding author on]. Participants have given informed consent for data availability [or ... consent has not been obtained from participants, but the data submitted are anonymized and the risk of identification is reduced ... or participants’ consent has not been obtained, but the potential benefits of making these data available justify the potential losses, since ...]" 
2.  If data are not made available
   "Data availability: no additional data are available." This option does not apply to clinical trials of drugs or medical devices.

For research other than clinical trials, data sharing statements are encouraged but not required. Authors may be asked to provide the raw data on which their article was based on during the review process and up to 10 years after publication.

Submission of Papers

Submission of a manuscript implies that: i) the work described has not been previously published (except in the form of an abstract or as part of a published lecture); ii) the work has not been considered for publication elsewhere; iii) the manuscript has been approved by all authors and, tacitly or explicitly, by the competent authorities where the work was carried out; iv) if accepted for publication, it is not published elsewhere in the same form, in English or in any other language, including electronically.
All manuscripts should be accompanied by a cover letter. In the cover letter assurance should be given that the manuscript is not under simultaneous consideration by any other journal. In the cover letter, authors should declare their potential conflicts of interest and provide a statement about authorship.
To verify originality, the article can be checked by an originality detection service.

Submission of Manuscript

Manuscripts are submitted through the Lusíadas Scientific Journal website
(https://lusiadasscientificjournal.pt/index.php/lsj/about/submissions).

Contact

In case of questions during submission, please contact: knowledgecenter@lusiadas.pt

Preparation of the Manuscript

Use of word processing software

Manuscripts should be submitted in Word format, with Times New Roman, size 12, line spacing 1.5. It is important that the file be saved in the native format of the word processor used. The text should be in single column format. Keep the layout of the text as simple as possible. To avoid unnecessary errors, we advise you to use the "spell check" and "grammar check" functions of your word processor.

Guidelines for Submission of Studies

Texts should be prepared according to the guidelines of the International Committee of Medical Journal Editors: Recommendations for the Conduct, Reporting, Editing and Publication of Scholarly Work in Medical Journals (ICMJE Recommendations) available at http://www.icmje.org. Lusíadas Sci J recommends the EQUATOR network publication guidelines (http://www.equator-network.org).
Checklists are available for various study designs, including: 

• Randomized controlled trials (CONSORT);
• Systematic reviews and meta-analyses* (PRISMA) and protocols (PRISMA-P);
• Observational studies (STROBE);
• Case reports (CARE);
• Qualitative research (COREQ);
• Diagnostic/prognostic studies (STARD);
• Economic evaluations (CHEERS);
• Pre-clinical animal studies (ARRIVE).

* Authors of systematic reviews should also provide a link to an additional file from the 'methods' section, which reproduces full details of the search strategy.

The acceptance criteria for all papers are the quality and originality of the research and its significance to the Lusíadas Sci J readers. Except where otherwise indicated, the manuscripts are submitted to blind peer review by two anonymous reviewers. Final acceptance or rejection is the Editor-in-Chief responsibility, who reserves the right to refuse any material for publication. Manuscripts should be written in a clear, concise, direct style so that they are intelligible to the reader. When contributions are deemed suitable for publication based on scientific content, the Editor-in-Chief reserves the right to modify the texts to eliminate ambiguity and repetition, and to improve communication between the author and the reader. If extensive changes are required, the manuscript will be returned to the author for revision. Manuscripts that do not meet the instructions for authors may be returned for modification prior to review.

Typology of Articles

Lusíadas Scientific Journal publishes articles of the following types:

1. Original Articles reporting clinical or basic research in the areas of interest of the journal (clinical trials, cohort studies, case-control studies, other observational studies);
2. Review Articles;
3. Systematic Reviews with or without Meta-Analysis;
4. Clinical Case/Case Study;
5. Images;
6. Editorials;
7. Letters to the Editor;
8. Perspectives;
9. Guidelines.

Authors should indicate in the cover letter which type of manuscript is being submitted for publication.

On the First Page/Title Page:

1. Title

Title in Portuguese and English, concise, specific and informative, without abbreviations and not exceeding 120 characters. The title may include a title complement with a maximum of 40 characters (including spaces).

2. Authors, Affiliations and ORCID IDs

On the authorship line, list the name of all authors (first and last name) and their affiliations (department, institution, city, country) and highest academic degree. Authors should also provide their ORCID iDs.

3. Financial Support

State all sources of funding, in the public or private domain, including scholarships that contributed to the completion of the work.
Examples:
For single agency grants: This work was supported by the [Funding Agency] under Grant [number xxxx].
For multiple agency grants: This work was supported by the [Funding Agency #1] under Grant [number xxxx]; [Funding Agency #2] under Grant [number xxxx]; and [Funding Agency #3] under Grant [number xxxx]. 

4. Corresponding Author

Clearly indicate who will handle correspondence at all stages of refereeing, publication and post-publication. Indicate postal address and e-mail of the Author responsible for correspondence concerning the manuscript.

5. Abstract and Keywords

A concise and factual abstract is required, capable of representing the content of the article alone, written in Portuguese and English. Information that does not appear in the manuscript cannot be included in the abstract. The abstract cannot refer to the text, contain citations or references to figures.
At the end of the abstract, a maximum of 6 keywords should be included in Portuguese and English using the terminology found in the Medical Subject Headings (MeSH), https://meshb.nlm.nih.gov/search 

Structured Abstract

A structured abstract, with appropriate section labels (Introduction, Methods, Results, and Conclusion), should provide the setting and purpose of the study, basic procedures (selection of study subjects or laboratory animals, observational and analytical methods), main results (statistical significance if possible), and main conclusions. It should emphasize new and important aspects of the study or observations.

6. Ethical Considerations

Included on this title page under the heading "Ethical considerations" should be the statement on "Protection of human and animal subjects", Confidentiality of data and informed consent, and Conflicts of interest.

7. Awards and Previous Presentations

Prizes and presentations of the study should be mentioned prior to the submission of the manuscript.

Text

The following pages of the manuscript should comply with the requirements defined for each type of article.

Original Articles

These refer to randomized clinical trials, intervention studies, cohort studies, case-control studies or other observational studies, cost-effectiveness analysis, among others.

Original articles should include the following sections: Introduction, Material and Methods, Results, Discussion and Conclusion, Acknowledgments (if applicable), References, Tables and Figures.

Original articles should not exceed 4000 words, up to 6 tables or figures and up to 60 references. The abstract should be structured, with a maximum of 350 words.
This typology of articles should follow the EQUATOR guidelines. 

Article structure

Introduction

State the objectives of the work and provide an adequate background, avoiding a detailed literature survey or a summary of the results.

Material and Methods

Provide sufficient detail to allow the work to be reproduced. Methods already published should be indicated by a reference: only relevant modifications should be described.

Results

Results should be clear and concise.

Discussion

This should explore the significance of the results of the work, not repeat them. A combined Results and Discussion section is often appropriate. Avoid extensive citations and discussion of published literature.

Conclusion

The main conclusions of the study may be presented in a short Conclusions section, which may stand alone or form a subsection of a Discussion or Results and Discussion section.

Narrative Review Articles

Review articles cover broad areas and should address a specific issue or a question relevant to clinical practice. They synthesize pre-existing ideas and suggest new ones. The focus should be an update on the current understanding of the etiology or pathophysiology of diseases, diagnostic and/or therapeutic considerations.
These articles are usually by invitation from the Editor-in-Chief. However, Lusíadas Scientific Journal occasionally accepts unsolicited review articles on important issues or recent advances. Before submitting a narrative review, it is advisable to send a brief outline of the article to the Editor-in-Chief (no more than 500 words) indicating the importance of the subject and why you are qualified to write it. An invitation for submission does not guarantee acceptance.
Review articles should not exceed 4000 words. They may have up to 6 tables or figures and up to 100references. The abstract should be unstructured with a maximum of 350 words.

Systematic Reviews and Meta-Analyses

Systematic reviews may or may not use statistical methods (meta-analyses) to analyze and summarize the results of the included studies.
Systematic reviews should be presented in the format of Introduction, Methods, Results, Discussion. In the Methods, a clear indication of the literature search strategy, data extraction, classification of evidence and analysis should be provided. PRISMA guidelines should be followed (http://www.prisma-statement.org/) and the protocol should be registered in PROSPERO (https://www.crd.york.ac.uk/prospero).
The text should not exceed 4000 words, excluding the structured abstract (maximum 350 words). It should not include more than 100 references, and up to 6 tables or figures.

Clinical Cases

The Clinical Case Report should include the following sections: Introduction, Clinical Case, and Discussion. The text cannot exceed 2000 words and 20 references. It should include an unstructured abstract not to exceed 150 words.
The normative CARE should be followed (http://www.care-statement.org/). Considering their nature, case reports should have a limited number of authors (less than 5).
If there are more than 5 co-authors, the cover letter should clearly indicate in detail the role of each author in the manuscript, in order to justify their inclusion in the authorship line according to the ICMJE criteria (http://www.icmje.org/).

The patient’s permission (next of kin, legal guardian) may be required. If the patient(s) described in these manuscripts is identifiable, the patient’s consent form should be completed and signed by the patient(s) (or guardian/legal representative) and submitted with the manuscript. Impairing patient identification by omitting scientifically irrelevant data is acceptable, but altering these data is not.

Editorials

The Editorials are the responsibility of the publishing group, requested by invitation by the Editor-in-Chief and will consist of comments on current topics or on articles published in the journal. They should not exceed 1200 words, with a maximum of 15 references, and may contain one table and one figure. There is no abstract.

Letters to the Editor

Letters to the Editor consist of critical comments on an article published in the journal or a short note on a particular issue or clinical case. Letters to the Editor should not exceed 600 words and 10 references and may include one figure or table. There is no abstract.

Medical Images

Medical Images is an important contribution to medical learning and practice. This section is intended for the publication of clinical, radiological, histological and surgical images. The title should be no longer than eight words. Authors should be a maximum of four. The images should be of high quality and educational value. Up to 4 figures are allowed. Captions should be brief and informative. Arrows or other symbols should be included as needed to facilitate understanding of the images. The text should not exceed 500 words and five references. It should include a brief clinical history and relevant physical examination data, laboratory tests and clinical progression as appropriate. There is no abstract. The patient’s permission (next of kin, legal guardian) may be required.

Perspective

This type of manuscript is submitted by invitation of the Editorial Board, however, spontaneous applications for publication are also subject to editorial consideration. It can cover a wide range of issues of interest in healthcare: current or emerging problems, health management and policy, ethics, history of medicine, connection to society, epidemiology, among others. An author who wishes to propose a manuscript in this section must send an abstract to the Editor-in-Chief, including the title and list of authors for evaluation. The text should not exceed 1200 words, 10 references, 2 tables and 2 figures. There is no abstract.

Guidelines

Recommendations for clinical practice should not exceed 4000 words, up to 6 tables or figures, and up to 100 references. The abstract should be no longer than 350 words. This type of article can be submitted by working groups organized within scientific meetings or associations, or groups of authors with specialized work carried out on the issue in question.

References

1. Citation in the Text

Make sure that all references cited in the text are also included in the reference list (and vice versa). References must be listed using Arabic numerals in the order in which they are cited in the text. References to personal communications and unpublished data should be made directly in the text and should not be numbered.
Personal communications must be duly authorized by the issuer of the communications, with the authors assuming responsibility for the authorization. Citing a reference as "in press" implies that the item has been accepted for publication. The names of the journals must be abbreviated according to PubMed style. References to articles published in journals should include the name of the first author followed by the names of the remaining authors (to a maximum of 6, thereafter et al should be used), the title of the article, the name of the journal and the year of publication, volume and pages, and DOI. Make sure that the data provided in the references are correct. When copying references, be careful because they may already have errors. The list of references should be added as part of the text and never as a footnote. Specific codes from the reference management program are not allowed.

2. Format

A detailed description of the formats of different reference types can be found in the "Uniform Requirements for Manuscripts Submitted to Biomedical Journals" (http://www.nlm.nih.gov/bsd/uniform_requirements.html). List all authors if there are six or less. Et al should be added if there are more than six authors. Title of the article, name of the journal, year, volume and pages.

3. Reference Style

Text: Indicate references in the text by number(s) in exponent. Authors may be referred to, but the reference number must always be given.
List: Order the references in the list in the order in which they appear in the text.

Examples:

1. Article reference:
   - With less than 6 authors:
   Amaral L, Carneiro-Leão L, Cernadas JR. Acute generalized exanthematous pustulosis due to clavulanic acid. J Allergy Clin Immunol Pract. 2020;8:1083-4. doi: 10.1016/j.jaip.2019.09.024.
   - With more than 6 authors:  
   Toscano M, Neves Z, Matias C, Carvalho M, Ribeiras R, Morgado F, et al. Pacemaker lead as an iatrogenic cause of right heart failure: Case report. Rev Port Cardiol. 2019;38:675.e1-675.e5. doi: 10.1016/j. repc.2018.01.014.
   - In press
   Roque D, Ferreira J, Monteiro S, Costa M, Gil V; Portuguese National Registry of Acute Coronary Syndromes Investigators. Understanding a woman’s heart: Lessons from 14 177 women with acute coronary syndrome. Rev Port Cardiol. 2020 (in press). doi: 10.1016/j.repc.2020.03.002.
2. Book reference:
   Schatzberg AF, Nemeroff CB. Essentials of clinical psychopharmacology. 3rd ed. Washington: American Psychiatric Association Publishing; 2013.
3. Book chapter reference:
   O’Connell MA, Jewell DM. Human resources management in group practice. In: Wolper LF, editor. Physician practice management: essential operational and financial knowledge. Sudbury: Jones Bartlett Publishers; 2005. p. 139-70.
4. Thesis and dissertation reference:
   Silva JL. Contribuição ao estudo da gravidez na adolescência. [Dissertação]. Fortaleza: Faculdade de Medicina, Universidade Federal do Ceará; 2015.
5. Web references:
   At the least, the full URL should be given and the date the document was consulted. Any other information, if known (author names, dates, reference to a source publication, etc.), should also be given. A.D.A.M. medical encyclopedia [Internet]. Atlanta: A.D.A.M.; 2005 [cited 2019 Mar 26]. Available from:http://www.nlm.nih.gov/medlineplus/ ncyclopedia.html

Footnotes

Footnotes should be avoided. When essential, they should be numbered consecutively and appear on the appropriate page.

Other Style Rules

Acknowledgments (Optional)

They should appear after the text, and before the references, in order to thank all those who contributed to the study, but who do not have authorship weight. In this section it is possible to thank all sources of support, whether it is financial, technological or advisory, as well as individual contributions.

Abbreviations

Do not use abbreviations or acronyms in the title and in the abstract and limit their use in the text. Non-widely accepted abbreviations should be well-defined in the first use, in full, immediately followed by the abbreviation in brackets, unless the abbreviation is a standard measuring unit. Excessive and unnecessary use of acronyms and abbreviations should be avoided.

Measuring Units

The units of the International System of Units must be used.
Length measures, height, weight, and volume must be expressed in units of the metric system (meter, kilogram,or liter) or their decimal multiples.
Temperatures should be given in degrees Celsius (ºC) and blood pressure in millimeters of mercury (mmHg), and hemoglobin in g/dL.
All hematological or biochemical measurements shall be referred to in the metric system according to the International System of Units (IS). 

Names of Drugs and Medical Devices

Accurately identify all drugs and products by their international non-proprietary name (INN). The use of commercial names of drugs (trademark) is not recommended, but where the use is mandatory, the product name should come after the INN name, in brackets, in lowercase, followed by the symbol that characterizes the trademark, in superscript (®). The same principle applies to medical devices.

Names of Genes, Symbols and Access Numbers

Genes and related structures should be assigned the official names and symbols provided by the National Center for Biotechnology Information (NCBI) or the HUGO Gene Nomenclature Committee. Prior to submitting a manuscript reporting large genomic data sets (e.g., protein or DNA sequences), the data sets should be deposited in a publicly available database, such as NCBI GenBank, and a full access number (and version number, if appropriate) should be provided in the Methods section.

Illustrations

Tables and Figures

Tables/Figures should be numbered in the order in which they are mentioned in the text and marked in Arabic numerals and identified.
Each figure and table included in the paper must be referred to in the text: "An abnormal immune response may be at the origin of the symptoms of the disease (Fig. 2)"; "This is associated with two other injuries (Table 1)".
Figure: When mentioned in the text is abbreviated to Fig., while Table is not abbreviated. In the captions both words are written in full.
Each table and figure must be accompanied by the respective caption, brief and clear. Captions should be self-explanatory.
Regarding the charts, it should be explicit whether the information includes individual values, means or medians, whether there is representation of the standard deviation and confidence intervals, and the sample size (n).
Photographs should include identifiers of scientifically relevant aspects (arrows and asterisks).
Color photographs may be published provided they are considered essential.
Each table should be used to show results by listing individual data or summarizing them, however they should not duplicate the results described in the text. They should be accompanied by a short but clear and explanatory title.
The units of measurement used should be indicated (in parentheses below the name at the top of each category of values) and the numbers expressed should be reduced to the clinically meaningful decimal places.
For the explanatory notes in the tables the following symbols and sequence should be used: *, †, ‡, §, ||, ¶, **, ††, ‡‡.

General Principles:

• Number the illustrations according to their sequence in the text.
• Provide the captions for the illustrations separately.
• Size the illustrations close to the desired dimensions of the published version.
• Submit each illustration in a separate file.

The inclusion of figures and/or tables already published implies the authorization of the copyright holder (author or editor).
Submission must be made separately from the text, according to the instructions of the platform.
Figure files should be provided in high resolution, 800 dpi minimum for charts and 300 dpi minimum for photographs.
The publication of color illustrations is free of charge, and Lusíadas Scientific Journal reserves the right to publish a black and white version in the printed version of the journal.
Graphic material must be submitted in one of the following formats: JPEG (.Jpg), Portable Document Format (.Pdf), PowerPoint (.ppt), TIFF (.Tif), Excel. 

Permission to Publish

In case of publication of tables from books or journals, the authors have the responsibility to obtaining permission from the authors of the works from which they are reproduced for such publication and will need to provide it in the submission.

Multimedia Files

Multimedia files should be sent in a separate file with the manuscript. The multimedia material should follow the production quality standards for publication without the need for any modification or editing. Acceptable files are MPEG, AVI or QuickTime formats.

Attachments/Appendices

When necessary, attachments should be used to present long or detailed surveys, descriptions of extensive mathematical calculations, and/or lists of items. They should be placed after the list of references, with captions if necessary. Long attachments, such as algorithms, surveys, and protocols, will only be published online; the URL will be provided in the printed article where the Attachment is cited. If there is more than one appendix, they should be identified as A, B, etc. Formulas and equations in appendices should be numbered separately: Eq. (A.1), Eq. (A.2), etc.; In a later appendix, Eq. (B.1) and so on. Likewise for tables and figures: TableA.1; FIG. A.1, etc.

Style

Lusíadas Scientific Journal follows the AMA Manual Style, 10th edition (http://www.amamanualofstyle.com) and ICMJE Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals (http://icmje.org/ recommendations). 

Article type	Abstract	Keywords	Main text structure	Max. words	Tables/figures	References
Original Article	Max. 350 words; structured (Introduction and Objectives, Methods, Results and Conclusion(s))	3-10	Introduction; Objectives; Methods; Results; Discussion; Conclusion(s); Acknowledgments, if any; References; and figure legends, if any	4000	Total up to 6	up to 60
Review Article	Max. 350 words; unstructured	3-10	Introduction; thematic sections at the discretion of the authors; Conclusion(s); Acknowledgements, if any; References; and figure legends, if any	4000	Total up to 6	up to 100
Systematic Review	Max. 350 words; Structured	3-10	Introduction, Methods, Results, Discussion and Conclusion(s); Acknowledgements, if any; References; and figure legends, if any	4000	Total up to 6	Up to 100
Case Report	Max. 150 words; unstructured	3-6	Introduction; Case report; Discussion; Conclusion(s) (optional); References; and figure legends, if any	2000	Up to 4	Up to 20
Images in Medicine	None	3-10	Unstructured	500	Up to 4 figures; no tables	Up to 5
Editorial	None	None	Unstructured	1200	Up to 1 table, 1 figure	Up to 15
Letter to the Editor	None	None	Unstructured	600	Up to 1 table, 1 figure	Up to 10
Perspectives	None	3-10	Unstructured	1200	Up to 2 figures; no tables	Up to 10
Guidelines	Max. 350 words; unstructured	3-10	Introduction; thematic sections at the discretion of the authors; Conclusion(s); Acknowledgements, if any; References; and figure legends, if any	4000	Total up to 6	Up to 100