Perspective Articles

Genetics and Oncology: It Takes Two to Tango

Main Article Content

Marta Amorim
Genetics, Medical, Genetic Predisposition to Disease, Genetic Testing, Neoplasms/genetics, Precision Medicine

Article Details

How to Cite
Perspective Articles


Ordem dos Médicos [consultado Jan 2023] Disponível em: (2014).

Max Roser and Hannah Ritchie - "Cancer". [consultado Jan 2023] Disponível em:

Basu NN, Hodson J, Chatterjee S, Gandhi A, Wisely J, Harvey J, et al. The Angelina Jolie effect: Contralateral risk-reducing mastectomy trends in patients at increased risk of breast cancer. Sci Rep. 2021;11:2847. doi: 10.1038/s41598-021-82654-x.

Liede A, Cai M, Crouter TF, Niepel D, Callaghan F, Evans DG. Risk-reducing mastectomy rates in the US: a closer examination of the Angelina Jolie effect. Breast Cancer Res Treat. 2018;171:435-42. doi: 10.1007/s10549-018-4824-9.

Xi Q, Jin S, Morris S. Economic evaluations of predictive genetic testing: A scoping review. PLoS One. 2023;18:e0276572. doi: 10.1371/journal.pone.0276572.

Brown NA, Elenitoba-Johnson KS. Enabling Precision Oncology Through Precision Diagnostics. Annu Rev Pathol. 2020;15:97-121. doi: 10.1146/annurev-pathmechdis-012418-012735.

Ngeow J, Eng C. Precision medicine in heritable cancer: when somatic tumour testing and germline mutations meet. NPJ Genom Med. 2016;1:15006. doi: 10.1038/npjgenmed.2015.6. P

Rose M, Burgess JT, O'Byrne K, Richard DJ, Bolderson E. PARP Inhibitors: Clinical Relevance, Mechanisms of Action and Tumor Resistance. Front Cell Dev Biol. 2020;8:564601. doi: 10.3389/fcell.2020.564601.

Chakravarty D, Johnson A, Sklar J, Lindeman NI, Moore K, Ganesan S, et al. Somatic Genomic Testing in Patients With Metastatic or Advanced Cancer: ASCO Provisional Clinical Opinion. J Clin Oncol. 2022;40:1231-58. doi: 10.1200/JCO.21.02767. Erratum in: J Clin Oncol. 2022;40:2068.

Food and Drug Administration. Novel Drug Approvals for 2023. [consultado Jan 2023] Disponível em:

Cohen SA, Liu MC, Aleshin A. Practical recommendations for using ctDNA in clinical decision making. Nature. 2023;619:259-68. doi: 10.1038/s41586-023-06225-y.

Brito-Rocha T, Constâncio V, Henrique R, Jerónimo C. Shifting the Cancer Screening Paradigm: The Rising Potential of Blood-Based Multi-Cancer Early Detection Tests. Cells. 2023;12:935. doi: 10.3390/cells12060935.

Padrik P, Puustusmaa M, Tõnisson N, Kolk B, Saar R, Padrik A, et al. Implementation of Risk-Stratified Breast Cancer Prevention With a Polygenic Risk Score Test in Clinical Practice. Breast Cancer. 2023;17:11782234231205700. doi: 10.1177/11782234231205700. P

Dixon P, Keeney E, Taylor JC, Wordsworth S, Martin RM. Can polygenic risk scores contribute to cost-effective cancer screening? A systematic review. Genet Med. 2022;24:1604-17. doi: 10.1016/j.gim.2022.04.020.